Article: Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Wang D; Schreurs BG Neurosci. Lett., 2010
Table 1Summary of membrane properties of rabbit hippocampal CA1 neurons.
Cell number (n) for Control, Chol, Chol+Copper was 25, 22, and 13, respectively. AP: Action potential; AP duration was measured at the width of 50% AP duration.*p<0.05 as compared to Control.**p<0.01 as compared to Control.***p<0.001 as compared to Control.¤p<0.05 as compared to Chol.¤¤p<0.01 as compared to Chol.¤¤¤p<0.001 as compared to Chol.
Membrane property | Control | Chol | Chol+Copper |
Vm (mV) | −66.5±0.71 | −68.1±1.03 | −60.2±3.07* |
Input resistance (MΩ) | 72.87±6.95 | 52.46±4.63* | 55.13±7.86 |
AP threshold (mV) | −44.08±1.72 | −43.66±1.76 | −43.87±1.23 |
AP amplitude (mV) | 87.3±2.89 | 89.24±2.91 | 69.23±2.63¤¤¤ |
AP duration (ms) | 1.66±0.10 | 1.19±0.10** | 0.81±0.07***,¤ |
AP rising duration (ms) | 0.46±0.03 | 0.38±0.03 | 0.31±0.03*** |
AP falling duration (ms) | 1.09±0.1 | 0.81±0.08* | 0.5±0.05***,¤¤ |
AHP (mV) | −5.14±1.04 | −2.31±0.79* | −6.25±1.45¤ |
Latency (ms) | 69.85±14.0 | 57.96±14.64 | 37.71±12.36 |
Current required for first elicited AP (nA) | 0.17±0.02 | 0.35±0.03*** | 0.32±0.04*** |